By Icon Health Publications

ISBN-10: 049700013X

ISBN-13: 9780497000134

ISBN-10: 1417541601

ISBN-13: 9781417541607

This can be a 3-in-1 reference ebook. It provides a whole clinical dictionary protecting thousands of phrases and expressions with regards to acidosis. It additionally provides vast lists of bibliographic citations. ultimately, it presents details to clients on tips on how to replace their wisdom utilizing quite a few net assets. The publication is designed for physicians, scientific scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with examine devoted to acidosis. in case your time is effective, this e-book is for you. First, you won't waste time looking the net whereas lacking loads of suitable details. moment, the e-book additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing thousands of websites.

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Additional info for Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Sample text

Cell viability, cytosolic free calcium and pH, mitochondrial membrane potential, lysosomal distribution and integrity, cytoskeletal status, plasma membrane distribution and integrity, and cell surface morphology will be evaluated in single individual hepatocytes during hypoxia by quantitative digitized video microscopy (DVM). DVM will allow the direct observation of the dynamics of organelles and molecules in living cells, providing new information about the roles of these components in cellular function.

We have licensed this technology from the University of Texas at Dallas and through the current funding mechanism intend to create even more pH responsive MRI agents, demonstrate their utility in vivo in animal models, and make them commercially to the biomedical research community. PROPOSED COMMERCIAL APPLICATION: Magnetic resonance imaging is widely used to detect tumors in humans, yet little physiological information is gained in a normal MRI exam. We plan to develop new pH sensitive contrast agents that can be safely injected into patients to determine the extracellular pH of tumors using a standard imaging protocol.

Studies will also be conducted on cells in culture and the isolated perfused tubule preparation. Because of the importance of NH3/NH4+ in regulating pH, these studies have significant physiological implications. The possibility that a gas, such as NH3, could be transported through an AQP or another carrier protein, is unique and suggest that its transport could be regulated. NH4+-specific transporters, as Rh glycoproteins may be, have never been described in mammalian cells before. These are new properties of NH3/NH4+ transport that will help explain the role of NH3 and NH4+ in acidosis and their effect on transport of other ions a well.

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Acidosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications


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