By J. D. Pagan, R. J. Geor
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Extra info for Advances in Equine Nutrition III
The few proliferating cells detected in the main lamellar region had a patchy distribution and were located at the PEL tips, not in cap-horn arcades. A 20-fold PI decrease between proximal and more distal lamellae suggests that most of the normal lamellae are nonproliferative and their main function is to suspend the distal phalanx within the hoof capsule. However, the most distal lamellae and the tubular hoof of the white line and dorsal sole had a PI approaching the proximal hoof, as expected in a zone in which considerable new hoof production occurs to create the white line and sole (Fig.
8,10 The stratum medium is considered to have an anatomic design that confers strength in all directions. Unlike bone, which is a living tissue and remodels to become stronger along lines of stress, the stratum medium is nonliving tissue but is anatomically constructed to resist stress in every direction and never to require remodeling. 11 It is in fact overengineered. The fully keratinized cells (corneocytes) of the tubular and intertubular hoof, cemented firmly to each other, form a continuum: the tough yet flexible stratum medium of the hoof wall.
By the early 1980s we rarely saw black walnut laminitis cases. Now the laminitis group at Missouri included Dr Jim Moore, and they became convinced that endotoxin, released by the death of gram-negative bacteria, was causing the laminitis. A laminitis symposium was held at the University of Missouri and a great debate regarding the blood supply to the foot ensued. Was it increased or decreased during the start of laminitis? It is a question still debated today. It was during this time that I began to question if phenylbutazone was really helping horses.
Advances in Equine Nutrition III by J. D. Pagan, R. J. Geor