By Mario D. Cordero, Benoit Viollet

ISBN-10: 3319435876

ISBN-13: 9783319435879

ISBN-10: 3319435892

ISBN-13: 9783319435893

AMPK has emerged as an enormous integrator of signs that keep an eye on strength stability during the rules of a number of biochemical pathways in eukaryotes.

This publication specializes in the consequences of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal versions. The contributions are written via prime specialists within the box and provides an intensive evaluate of the present wisdom of AMPK biology and the function of AMPK in wellbeing and fitness and ailment.

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3 AMPK in Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Fatty Acid Uptake . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Lipid Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Acetyl-CoA Carboxylase and Fatty Acid Oxidation .

Eur J Biochem/FEBS 269(15):3751–3759 Krawiec BJ, Nystrom GJ, Frost RA, Jefferson LS, Lang CH (2007) AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. Am J Physiol Endocrinol Metab 292(6):E1555–E1567 Kreuz S, Schoelch C, Thomas L, Rist W, Rippmann JF, Neubauer H (2009) Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes. Diabetes Metab Res Rev 25(6):577–586 Lage R, Dieguez C, Vidal-Puig A, Lopez M (2008) AMPK: a metabolic gauge regulating wholebody energy homeostasis.

Eng Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428 (6982):569–574 Moreno D, Viana R, Sanz P (2009) Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. Int J Biochem Cell Biol 41(12):2431–2439 Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight.

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AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet

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